When this was announced I messed with some numbers a bit, and compared the DSi release price (in Yen) to the NA release price (in US dollars). If you did a straight conversion of Yes to USD with the DSi, it came out to $225. The DSi was $180 here though, which is 80% of the full conversion price. If you do the same 80% drop, you get like $249 for the 3DS. I would expect the price point to be $250 or lower in the US.
Of course I haven't bought a Nintendo handheld since the GBA SP. I prefer short session games like puzzle games, and would rather play more engrossing games at home on my TV. Also I just don't have the need for a handheld system. (Cant' play while driving, if I play in a car I get motion sickness anyway, don't live somewhere that I can take the bus places anymore, and even when I did I didn't like seedy fucking people getting in my business about my expensive electronics.)