I've had that exact problem with McAfee Enterprise Edition (from my university and office). Every once in a while it would just break and I'd have to reinstall it. If for whatever reason I ever disabled it (for an install or whatever), it would just break as well.
Still, McAfee ViruScan Enterprise was my favourite from McAfee for the simple reason that it was the least bloated of all their software.
Kaspersky was pretty good for a while, except for one little problem: it always fucked up m network. I'm not even talking about Kasperskpy Internet Security, just the Antivirus. I installed it and suddenly my internet goes out and my computer is inaccessible to the local network. Checked online for solutions and it seemed to happen to only a few people. The best that could be done was to get the internet back but the LAN was still inaccessible.
Panda was one I kinda liked until they started charging annual subscription fees. I understand the reason for it since updating virus databases is a service but I, like everyone else, would rather go for the simple and free solution.
Norton/Symantec is one suite I have had nothing but trouble with since its creation. Never been a fan of any of their products. Bloatware and system-wide domination, suddenly my PC is "Norton's Computer" and I'm a guest on my own system.
Yeah we use McAfee ViruScan Enterprise Edition here at work. Sorry I didn't specify the Enterprise Edition part.
Kaspersky used to be good, mostly because their big trick was to put a hash of each file in an alternate data stream. Upon the next scan it would generate another hash. If the new hash and the hash in the alternate data stream were the same, it would assume the file is unmodified and not scan it. This really did wonders for the scan speed and it worked pretty well. The downside is all those alternate data streams remained forever.
After awhile, Kaspersky's speed advantage disappeared and they suffered in market share because the interface is pretty weird and the localization isn't great.
I almost bought Panda after reading a few reviews but then I found some other comparison tests where it did very poorly so I kept researching and eventually settled on Eset NOD32.
While I hate anything Norton, I don't hate Symantec Endpoint Protection 11.0. It is pretty good for a corporate network and isn't too intrusive. It's also not as resource intensive as many past Norton/Symantec efforts. It's not super great for home users because its strengths are all the sweet things you can do with it in a centralized management environment of multiple clients. It also doesn't support right-click-scan-this like most other home or corporate AV+AS products do but it has a good scanning engine and is very stable.
Nod32 is my favorite. Works very well, and detects a lot of stuff.
Yep, that's what I use too. I have had it block several web attacks and virus-ridden downloads for me and it uses resources very efficiently.
I was trying to push the consulting firm I used to work for to resell Eset NOD32 (they came out with a management console and managed client when I was still there), but we were a Symantec partner so we mostly sold Endpoint Protection with the occasional Trend Micro Officescan or Worry-Free Business Security for people who ran for the hills when someone said the word "Symantec".